The ethanol extract of the rhizome of Curculigo orchioides Gaertn. (Hypoxidaceae) was evaluated for its analgesic and anti-inflammatory activities. The analgesic effect was studied using modified Eddy’s hot plate method, while the anti-inflammatory effect was investigated using carrageenan induced paw oedema in rats at different dose level 100, 300 and 500 mg/kg. The results of the study showed that the anti inflammatory potency of the extracts was compared with standard indomethacin (10 mg/kg). The ethanol extract showed significant reduction of edema in carrageenan induced rat paw edema model. The result indicated that the extracts exhibited dose dependent effect on inflammation i.e. 22.45%, 35.62% and 39.03% inhibition at doses level of 100 mg/kg, 300mg/kg and 500 mg/kg respectively. While ethanolic extract of C. orchioides were investigated for antinociceptive activity using modified Eddy’s hot plate method in albino wistar rats at different time intervals, 15, 30, 60, 120 min. Asprin dose (100mg/kg) was used as a reference. Ethanolic extract showed antinociceptive effect significantly increased the reaction time in hot-plate test throughout the observation period of 120 min. The 500 mg/kg dose of ethanolic extract showed maximum antinociceptive as well as anti-inflammatory effect than 100 and 300 mg/kg doses. The effect of ethanolic extract was found in dose dependent manner in both activities (P < 0.01). Phytochemical screening of the extract revealed the presence of alkaloids, flavonoids, saponins, steroids and tannins. The results showed that the extract contains some pharmacologically active principles and lend pharmacological credence to the ethnomedical use of the plant in the management of pain and inflammatory conditions.
Loading....